Lafayette Instrument Logo
Lafayette Instrument Logo

DETAILS

Lafayette Instrument Company is pleased to offer a touch screen version of the Progressive Ratio (PR) and Effort Related Choice (ERC) tasks. The touch screen version of the PR and ERC tasks are designed to be equivalent to the more usual tasks done with levers and nose pokes. Comparing the touch screen tasks to versions based on levers and nose pokes:

  • The PR task is very easy and quick to train - typically it takes 16 days to train naïve mice to reach stable PR performance, ready for pharmacological validation.
  • PR performance is very stable across several days (greater stability than has been observed with non-touch screen versions of the task).
  • Performance can be modulated bi-directionally with systemic pharmacology so the task is sensitive to both stimulation and inhibition. Using the same compounds as in non-touch screen versions of the task found similar effects, suggesting the touch screen version interacts with the same neurobiological systems.
  • Comparing it to the non-touch screen literature, it appears that the touch screen paradigm produces
    • less variable data and consequently easier detection of significant effects.
    • more sensitive to manipulations which promote PR performance and therefore useful for screening of drugs to alleviate low motivation.
    • conversely, may also be less sensitive to drugs which suppress performance, relative to non-touch screen versions.
  • The touch screen ERC task in mice shows the same behavioral performance shift previously reported in the rat lever press literature, suggesting the touch screen version interacts with the same neurobiological systems as the non-touch screen version.

DESCRIPTION

The mouse has to touch a white square X number of times to receive a reward. X can be the same for all trials (Fixed Ratio) or progressively increase as the experiment proceeds (Progressive Ratio).

The ERC is the same as the Fixed Ratio Task, except food is placed in the chamber, so that the mouse is required to choose between expending physical effort to obtain a highly preferred food or expending much less effort to freely consume less preferred food.The Task suite of programs supplied includes all training schedules and analysis filters.

REFERENCE

Heath CJ, Bussey TJ, Saksida LM., Motivational assessment of mice using the touchscreen operant testing system: effects of dopaminergic drugs. Psychopharmacology, 2015

NEXT EVENT: Society for Neuroscience,  November 3 - 7, 2018     Details >>

CONTACT US

Lafayette Instrument Company
3700 Sagamore Pkwy N
Lafayette, IN 47904

Phone: (765) 423-1505
Fax: (765) 423-4111
info@lafayetteinstrument.com

Home | Products | Support | About | Sitemap | Privacy

Copyright © 2009 - 2018 Lafayette Instrument Company. All Rights Reserved.


Top

PRODUCT SEARCH

Use this form to search for products from the Lafayette Instrument Online Family.



CONTACT US

Lafayette Instrument Company
3700 Sagamore Pkwy N
Lafayette, IN 47904

Phone: (765) 423-1505
Fax: (765) 423-4111

info@lafayetteinstrument.com

Copyright © 2009 - 2018 Lafayette Instrument Company. All Rights Reserved.