RELATED CATEGORIES
Bussey-Saksida Touch Systems > Chambers and Components for Mice
ABET II Interface and Software > ABET II Applications > Bussey Applications
PAIRED-ASSOCIATE LEARNING TASK - PAL - FOR MICE
Model 89541
DETAILS
In humans a similar task has proved to be highly effective for the early detection of Alzheimer's disease. In the PAL task for rodents, subjects learn and remember which of three objects goes in which of three spatial locations. On a given trial, two different objects are presented; one in its correct location; the other in an incorrect location. The subject must choose which stimulus is in the correct location. The task has been shown to be sensitive to cholinergic transmission and to hippocampal dysfunction and can dissociate glutamate from acetylcholine receptor function in the hippocampus.