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Bussey-Saksida Touch Systems > Chambers and Components for Mice
For more information about the ever expanding amount of published research using our Touch Screen Systems, visit the DOWNLOADS and SCIENCE sections! For more news about the system, check out our news page!
Look to Lafayette Instrument Company for a "Science above Hardware" approach not found from any other supplier. The fully validated chambers described below are supported by ready to run ABET II Touch Paradigms including images, and a Whisker ® Server-based Controller for up to four test chambers. Plus, we provide the ability for the user to write their own scheduling, with web-based training. ABET II Touch software gives you ease of use, programming power, data analysis, versatility, and flexibility.
Visit DOWNLOADS for videos of these tasks.
VISUAL DISCRIMINATION AND REVERSAL TASK (VDR)
Age-related impairments in the R6/2 Huntington's disease mouse model
Morton, Skillings, Bussey & Saksida (2006) Nature Methods
PAIRED ASSOCIATE LEARNING TASK (PAL)
Intra-hippocampal infusions of MK-801 impair performance of the PAL task
But perhaps the most promising data from this task comes from our studies using donepezil, an acetylcholinesterase inhibitor that is a commonly prescribed drug for AD in the UK. Donepezil enhanced performance on PAL in a dose-dependent manner. This result shows that PAL is able to detect cognitive enhancements, as well as impairments.
LOCATION DISCRIMINATION TASK (LD)
McTighe, Mar, Romberg, Bussey & Saksida (2009) NeuroReport
Neurogenesis knock-down impairs pattern separation in the Location Discrimination Task
Clelland, Choi, Romberg, Clemenson, Fragniere, Tyers, Jessberger, Saksida, Barker, Gage & Bussey (2009) Science
Dorsal hippocampal lesions impair pattern separation in the Location Discrimination Task
McTighe, Mar, Romberg, Bussey & Saksida (2009) NeuroReport
AUTOSHAPING
Data from C57/Bl6 mice on the Autoshaping task. A stimulus (white rectangle) is shown on either the left or right of the screen for (usually) 10 seconds. Over trials the animal learns that the CS+ predicts reward and makes increasingly more responses to the CS+, and fewer responses to the CS-.
Chamber shown with modular panel walls (Model 80614-3)
and corresponding reward trough (Model 80614-17).
Lecture Poster put together for Prof. Tim Bussey and the Distinguished Lecture Series located at Seoul National University on September 21, 2011.
Prof. Tim Bussey's profile at the University of Cambridge.
Details on the usage of Bussey-Saksida Touchscreen Chambers at Western University.
Improving cognitive testing on animals to treat human disorders: Technology developed at the University of Cambridge is transforming the way cognitive tests are performed on animals, leading to more directed experiments and ultimately aiding development of new drugs to treat schizophrenia and other neurocognitive disorders.
Guardian article on recent research indicating why regular exercise benefits brain cell growth.
BBC Article on recent research indicating why regular exercise benefits memory.
BBC Article on recent research indicating why regular exercise benefits brain power. Based on a Cambridge University study.
Abstract and graph presented at British Association for Psychopharmacology (BAP) 2010.
Featured application plans to use touch screens with microdialysis for sampling in the extracellular space. As shown in the image our design enables the lines to the animals to be as short as possible (the entry point to the chamber are at the side at the connection panel with the cooling fan) and the carousel can be rolled in and out on a shelf.
Bussey-Saksida Touch Screen Chambers for Rodents
CamTouch Technical Standard
Touch Screen System Cleaning Tips
Rodent Touchscreen Bibliography
Prof. Bussey's Profile
Start running and watch your brain grow, say scientists:
Physical exercise helps brains grow, mouse study finds:
Running could help jog memory and help brain grow, says Cambridge study:
Pairwise discrimination followed by reversal in C57BL6/J using mouse touchscreen operant boxes.
Autoshaping and VDR in Campden Instruments Touchscreen Chambers
Whisker: A client–server high-performance multimedia research control system
New translational assays for preclinical modelling of cognition in schizophrenia: The touchscreen testing method for mice and rats
Inside the Minds of Mice and Men
The Drug Deadlock
All in the mind of a mouse
Bussey Rodent Touch Screen Biography List
Cognitive Abilities on Transitive Inference Using a Novel Touchscreen Technology for Mice
Optimization of Touchscreen-Based Behavioral Paradigms in Mice: Implications for Building a Battery of Tasks Taxing Learning and Memory Functions
Touchscreen-paradigm for mice reveals cross-species evidence for an antagonistic relationship of cognitive flexibility and stability
Touchscreen-Based Cognitive Tasks Reveal Age-Related Impairment in a Primate Aging Model, the Grey Mouse Lemur (Microcebus murinus)
Improving cognitive testing on animals to treat human disorders
Touchscreens at Western University's TCN Laboratory
Cleaning your Campden Touch Screen Unit
Category: Neuroscience
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Mouse Touch Screen Visual Discrimination Video
Mouse Touch Screen Correct AutoShaping Video
Mouse Touch Screen Incorrect AutoShaping Video
PAL task with WT C57BL/6 Mouse
Pairwise Discrimination and Reversal task, C57 Black sixer
Pairwise Discrimination and Reversal Task, DBA C57
Location Discrimination Task, DBA C57
Mouse Progressive Ratio Task