The Model 80391 Sleep Fragmentation Chamber is used to provide researchers with the necessary tools for sleep fragmentation studies in both mice and rats. The 80391 maintains an animal environment that is virtually identical to that used in the original 80390 Chamber. The divider wall has been removed since a much faster sweep time is now possible. The sweep bar, food hopper, ad lib water and ventilated lid remain the same. The living environment is now independent of the drive mechanism to reduce noise and greatly facilitate cleaning. It resembles a standard living environment that includes food and water support. The height of the sweeper bar is adjustable to accommodate bedding.
The cycle time selector includes a variety of different cycle times. The continuous sweep setting now takes just 7.5 seconds. Selectable inter-sweep cycle values start at 0.25 minutes (15 seconds) all the way up to 30 minutes. Alternately, sweeps may be initiated from a remote device.
TNF-a and Temporal Changes in Sleep Architecture in Mice Exposed to Sleep Fragmentation [PLoS ONE, 2012]
Human apolipoprotein E4 targeted replacement in mice reveals increased susceptibility to sleep disruption and intermittent hypoxia [Am J Physiol Regul Integr Comp Physiol., 2012]
Socially Isolated Mice Exhibit a Blunted Homeostatic Sleep Response to Acute Sleep Deprivation Compared to Socially Paired Mice [Brain Res, 2013]
American Journal of Respiratory and Critical Care Medicine, 2011 Dec 1;184(11), 1305-1312
Chronic sleep fragmentation promotes obesity in young adult mice [Obesity, 2013]
Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-a pathway [Journal of Neuroinflammation, 2012]
Sleep fragmentation promotes NADPH oxidase 2-mediated adipose tissue inflammation leading to insulin resistance in mice [International Journal of Obesity, 2013]
Integrative miRNA-mRNA Profiling of Adipose Tissue Unravels Transcriptional Circuits Induced by Sleep Fragmentation [PLoS ONE, 2012]